EP-1173: Impact of plasma Epstein-Barr virus-DNA and gross tumor volume on prognosis of nasopharyngeal cancer

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Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma

This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with the tumor volume and prognosis in patients with locally advanced nasopharyngeal carcinoma (NPC). A total of 165 patients with newly diagnosed locally advanced NPC were identified from September 2011 to July 2012. EBV-DNA was detected using fluorescence quantitative polymerase chain reac...

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Epstein-Barr virus DNA in serum/plasma as a tumor marker for nasopharyngeal cancer.

Nasopharyngeal cancer (NPC) constitutes a type of carcinoma encountered frequently in Southern China, among Eskimos of the Arctic region, and to a lesser extent in Southeast Asia. Because EBV DNA present in plasma or serum of NPC patients has proven to represent a promising noninvasive tumor marker, the present study was designed to determine the incidence of serum/plasma EBV DNA by nested PCR ...

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Epstein-Barr virus genes and nasopharyngeal cancer

EBV is an enveloped virus with double-stranded DNA genome that encodes more than 85 genes (6). The viral genome consists of a series of 0.5-kb terminal direct repeats and internal repeat sequences that have most of the coding capacity (7). Two subtypes of EBV are known to infect human beings: EBV-1 and EBV-2. The gene organization that code for the EBV nuclear antigen (EBNA-2, EBNA3a, b, c) dif...

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Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

BACKGROUND Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for nasopharyngeal carcinoma. We conducted a prospective study to investigate whether EBV DNA in plasma samples would be useful to screen for early nasopharyngeal carcinoma in asymptomatic persons. METHODS We analyzed EBV DNA in plasma specimens to screen participants who did not have symptoms of nasopharyngeal carci...

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ژورنال

عنوان ژورنال: Radiotherapy and Oncology

سال: 2018

ISSN: 0167-8140

DOI: 10.1016/s0167-8140(18)31483-x